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Commentary by Paul R. Lichter, MD

JAMA. 2002;288(20):2607-2608.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

ARCHIVES OF OPHTHALMOLOGY

Reduction of Intraocular Pressure and Glaucoma Progression: Results From the Early Manifest Glaucoma Trial

Anders Heijl, MD, PhD; M. Cristina Leske, MD, MPH; Bo Bengtsson, MD, PhD; Leslie Hyman, PhD; Boel Bengtsson, PhD; Mohamed Hussein, PhD; for the Early Manifest Glaucoma Trial Group

Objective  To provide the results of the Early Manifest Glaucoma Trial, which compared the effect of immediately lowering the intraocular pressure (IOP), vs no treatment or later treatment, on the progression of newly detected open-angle glaucoma.

Design  Randomized clinical trial.

Participants  Two hundred fifty-five patients aged 50 to 80 years (median, 68 years) with early glaucoma, visual field defects (median mean deviation, –4 dB), and a median IOP of 20 mm Hg, mainly identified through a population screening. Patients with an IOP greater than 30 mm Hg or advanced visual field loss were ineligible.

Interventions  Patients were randomized . . . [Full Text of this Article]

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