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Lawrence J. Appel, MD, MPH

JAMA. 2002;288:3039-3042.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Quite simply, the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) is one of the most important trials of antihypertensive therapy. For decades, experts have passionately debated which class of drugs should be initial therapy for hypertension. Resolution of this issue, which has enormous clinical, public health, and economic implications, comes at a time of intense pressure to reduce health care costs while improving clinical outcomes. In this setting, the ALLHAT results, reported in this issue of THE JOURNAL, are particularly noteworthy, because there is no cost-quality tradeoff; the most effective therapy was also the least expensive.¹

The magnitude of the hypertension epidemic is enormous. For individuals aged 55 to 65 years, the lifetime probability of developing hypertension is 90%.² Across the United States, more than 40 million adults aged 25 years and older have hypertension.³ Of these, 21.9 million are treated with . . . [Full Text of this Article]

Author Affiliation: Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Md.

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