This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (70)  • Contact me when this article is cited  Related Content  • Related letter  • Related article  • Similar articles in JAMA  Topic Collections  • Hypertension  • Alert me on articles by topic  Social Bookmarking   What's this?

Lawrence J. Appel, MD, MPH

JAMA. 2002;288:3039-3042.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Quite simply, the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) is one of the most important trials of antihypertensive therapy. For decades, experts have passionately debated which class of drugs should be initial therapy for hypertension. Resolution of this issue, which has enormous clinical, public health, and economic implications, comes at a time of intense pressure to reduce health care costs while improving clinical outcomes. In this setting, the ALLHAT results, reported in this issue of THE JOURNAL, are particularly noteworthy, because there is no cost-quality tradeoff; the most effective therapy was also the least expensive.¹

The magnitude of the hypertension epidemic is enormous. For individuals aged 55 to 65 years, the lifetime probability of developing hypertension is 90%.² Across the United States, more than 40 million adults aged 25 years and older have hypertension.³ Of these, 21.9 million are treated with . . . [Full Text of this Article]

Author Affiliation: Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Md.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED LETTER

Long-term Cardiovascular Consequences of Diuretics vs Calcium Channel Blockers vs Angiotensin-Converting Enzyme Inhibitors

JAMA. ;289():2068-2068.
FULL TEXT  

RELATED ARTICLE

Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

JAMA. ;288():2981-2997.
FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Are Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Especially Useful for Cardiovascular Protection?
Ong
J Am Board Fam Med 2009;22:686-697.
ABSTRACT | FULL TEXT  

Thiazide Effects and Adverse Effects: Insights From Molecular Genetics
Ellison and Loffing
Hypertension 2009;54:196-202.
FULL TEXT  

Beyond the Randomized Clinical Trial: The Role of Effectiveness Studies in Evaluating Cardiovascular Therapies
Nallamothu et al.
Circulation 2008;118:1294-1303.
FULL TEXT  

ANG II provokes acute trafficking of distal tubule Na+-Cl cotransporter to apical membrane
Sandberg et al.
Am. J. Physiol. Renal Physiol. 2007;293:F662-F669.
ABSTRACT | FULL TEXT  

Improving blood pressure control through provider education, provider alerts, and patient education: a cluster randomized trial.
Roumie et al.
ANN INTERN MED 2006;145:165-175.
ABSTRACT | FULL TEXT  

Redistribution of distal tubule Na+-Cl- cotransporter (NCC) in response to a high-salt diet
Sandberg et al.
Am. J. Physiol. Renal Physiol. 2006;291:F503-F508.
ABSTRACT | FULL TEXT  

Systemic Administration of Local Anesthetics to Relieve Neuropathic Pain: A Systematic Review and Meta-Analysis
Tremont-Lukats et al.
Anesth. Analg. 2005;101:1738-1749.
ABSTRACT | FULL TEXT  

WNK1 Kinase Polymorphism and Blood Pressure Response to a Thiazide Diuretic
Turner et al.
Hypertension 2005;46:758-765.
ABSTRACT | FULL TEXT  

Translating Research into Practice: Are Physicians Following Evidence-Based Guidelines in the Treatment of Hypertension?
Holmes et al.
Med Care Res Rev 2004;61:453-473.
ABSTRACT  

PROTECT: A coordinated stroke treatment program to prevent recurrent thromboembolic events
Ovbiagele et al.
Neurology 2004;63:1217-1222.
ABSTRACT | FULL TEXT  

ALLHAT: Setting the Record Straight
Davis et al.
ANN INTERN MED 2004;141:39-46.
ABSTRACT | FULL TEXT  

Effects of chemical chaperones on partially retarded NaCl cotransporter mutants associated with Gitelman's syndrome in a mouse cortical collecting duct cell line
de Jong et al.
Nephrol Dial Transplant 2004;19:1069-1076.
ABSTRACT | FULL TEXT  

Secondary prevention for stroke and transient ischaemic attacks: PROGRESS is about reducing blood pressure, not promoting drugs
Duerden
BMJ 2004;328:896-897.
FULL TEXT  

ACE INHIBITORS vs. DIURETICS FOR HYPERTENSION
Journal Watch Cardiology 2004;2004:4-4.
FULL TEXT  

Relationship between Blood Glucose Control, Pathogenesis and Progression of Diabetic Nephropathy
Nosadini and Tonolo
J. Am. Soc. Nephrol. 2004;15:S1-5.
ABSTRACT | FULL TEXT  

Overcome Clinical Inertia to Control Systolic Blood Pressure
O'Connor
Arch Intern Med 2003;163:2677-2678.
FULL TEXT  

Risk factors for thiazide-induced hyponatraemia
Chow et al.
QJM 2003;96:911-917.
ABSTRACT | FULL TEXT  

Management of Glomerular Proteinuria: A Commentary
Wilmer et al.
J. Am. Soc. Nephrol. 2003;14:3217-3232.
ABSTRACT | FULL TEXT  

Primary Prevention of Coronary Heart Disease in the Elderly
Dornbrook-Lavender et al.
The Annals of Pharmacotherapy 2003;37:1654-1663.
ABSTRACT | FULL TEXT  

Functional Expression of the Human Thiazide-Sensitive NaCl Cotransporter in Madin-Darby Canine Kidney Cells
de Jong et al.
J. Am. Soc. Nephrol. 2003;14:2428-2435.
ABSTRACT | FULL TEXT  

Comprehensive Evaluation of the Older Woman
Amin et al.
Mayo Clin Proc. 2003;78:1157-1185.
ABSTRACT  

Angiotensin-Converting-Enzyme Inhibitors and Diuretics for Hypertension
Pickering et al.
NEJM 2003;349:90-93.
FULL TEXT  

Drug treatment of hypertension: implications of ALLHAT
Williams
Heart 2003;89:589-590.
FULL TEXT  

Diabetic Nephropathy in Type 2 Diabetes Prevention and Patient Management
Wolf and Ritz
J. Am. Soc. Nephrol. 2003;14:1396-1405.
FULL TEXT  

Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT): Practical Implications
Oparil
Hypertension 2003;41:1006-1009.
FULL TEXT  

Long-term Cardiovascular Consequences of Diuretics vs Calcium Channel Blockers vs Angiotensin-Converting Enzyme Inhibitors
Ong
JAMA 2003;289:2068-2068.
FULL TEXT  

Finally, the ALLHAT Results for Hypertension
JWatch Gastroenterology 2003;2003:5-5.
FULL TEXT  

The Thiazide-Sensitive Na-Cl Cotransporter and Human Disease: Reemergence of an Old Player
Ellison
J. Am. Soc. Nephrol. 2003;14:538-540.
FULL TEXT  

Use a Thiazide Diuretic First for Hypertension
Journal Watch Cardiology 2003;2003:1-1.
FULL TEXT  

Finally, the ALLHAT Results for Hypertension
JWatch General 2003;2003:1-1.
FULL TEXT