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Does Sex Matter?

Judith S. Hochman, MD; Jacqueline E. Tamis-Holland, MD

JAMA. 2002;288:3161-3164.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In 1960, the American Heart Association (AHA) sponsored a conference in Portland, Ore about women and cardiovascular disease (CVD) entitled "How I Can Help My Husband Cope With Heart Disease." Today, recognizing that cardiovascular disease is the leading cause of death for women older than 50 years, the AHA now routinely holds conferences about heart disease in women, and the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of Research on Women's Health devote substantial attention to this area.

Do women and men respond to cardiovascular therapies in the same way? For the most part, yes. However, biological differences, down to the cellular level, might account for different therapeutic effects and adverse responses.¹ For example, women are at greater risk from drugs that prolong the QT interval, including antiarrhythmics, antibiotics, and antihistamines.² Similarly, in patients with congestive . . . [Full Text of this Article]

Author Affiliations: St Luke's-Roosevelt Hospital Center and Columbia University, New York, NY.

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