This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on ISI (12)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To the Editor: In their look-back investigation, Dr Kopko and colleagues¹ reported that 36% of patients who received transfusions from a frequent plasma donor had reactions consistent with transfusion-related acute lung injury (TRALI). They also found that the donor had an anti-5b, a granulocyte-specific alloantibody, which has been associated with TRALI in both humans and in animal models.^2-3

I performed a similar clinical look-back investigation of a frequent apheresis platelet and plasma donor. The donor was a gravida 3, para 3 woman, who had donated a total of 16 apheresis platelet concentrates and 4 units of fresh frozen plasma over a 3-year period. Of 20 recipients, a transfusion reaction was identified in 3 patients. All 3 had evidence of respiratory involvement, manifested by coughing, wheezing, labored breathing, tachypnea, and oxygen desaturation. Two patients also had radiographic evidence of bilateral pulmonary infiltrates. One patient required a short course of mechanical ventilation. . . . [Full Text of this Article]

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Transfusion-related acute lung injury
Silliman et al.
Blood 2005;105:2266-2273.
ABSTRACT | FULL TEXT  

Verification of implantable cardioverter defibrillator (ICD) interventions by nonlinear analysis of heart rate variability - preliminary results
Przybylski et al.
Europace 2004;6:617-624.
ABSTRACT | FULL TEXT