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Neal L. Benowitz, MD

JAMA. 2002;288:497-499.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Well-documented racial differences in drug response^1-3 have led to considerable debate about "racial profiling" of pharmacotherapy.^4-5 Still, it is argued that race is a biologically meaningless term,⁴ and an understanding of physiology and the genetic underpinnings of drug response is a better way to target therapy. Furthermore, an individualized approach to pharmacotherapy with monitoring of patient response and modification of therapy as necessary might be just as effective as race-guided therapy. Whether to consider race in drug therapy has important implications for physicians, drug developers, and regulators. In this issue of THE JOURNAL, Ahluwalia and colleagues⁶ present the results of a clinical trial of sustained-release bupropion hydrochloride (bupropion SR) to aid smoking cessation in African American smokers treated at an inner-city community health center. The study demonstrates efficacy of bupropion, but the study design and resultant data raise questions about the ultimate value of pharmacotherapy trials . . . [Full Text of this Article]

Author Affiliation: Division of Clinical Pharmacology and Experimental Therapeutics, San Francisco General Hospital, University of California, San Francisco.

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