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Erectile Dysfunction and Hepatitis C Virus Infection
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To the Editor: Hepatitis C virus (HCV) infection has been associated with immune-mediated manifestations such as glomerulonephritis, thyroiditis, peripheral neuropathy, sicca syndrome, arthritis, and mixed cryoglobulinemia.1-2 Although erectile dysfunction has been anecdotally reported in patients with HCV-related chronic hepatitis, it is unclear whether this is related to superimposed liver failure, to interferon alfa treatment, or to the disease process itself.3
Methods
We evaluated the prevalence of erectile dysfunction in 207 patients with HCV infection (identified by serum anti-HCV antibodies and HCV RNA), including 105 with chronic hepatitis and 102 with HCV-associated cryoglobulinemic vasculitis.2 Patients were consecutively recruited at liver and rheumatology clinics at a university hospital. Exclusion criteria were age older than 55 years, interferon alfa treatment in the last year, or presence of diabetes, renal failure, hypothyroidism, human immunodeficiency virus infection, or concurrent cardiovascular or psychiatric disorders. All patients gave informed consent for the study, which was approved by the . . . [Full Text of this Article]
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