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Translating Biomedical Research to the Bedside
A National Crisis and a Call to Action
Roger N. Rosenberg, MD
JAMA. 2003;289:1305-1306.
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The doubling of the National Institutes of Health (NIH) budget in recent years,1-2 the publication of the initial sequence and analysis of the human genome in 2001,3-4 and advances in molecular biology, neuroscience, immunology, biomedical engineering, and functional magnetic resonance imaging suggest that these remarkable achievements in clinical and basic science research are being successfully translated to the clinic and bedside. There is an assumption that the recent exponential growth of scientific information about disease, as evidenced by the substantial increase in the numbers of published articles in biomedical journals, heralds a rapid move to improve human health.
This illusion is the subject of an intense analysis begun in June 2000 by the Clinical Research Roundtable (CRR) at the Institute of Medicine, as reported in this issue of THE JOURNAL by Sung et al.5 The CRR represents a group of stakeholders in the nation's clinical research . . . [Full Text of this Article]
Author Affiliation: Department of Neurology, University of Texas Southwestern Medical Center, Dallas. Dr Rosenberg is Editor of Archives of Neurology.
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JAMA. 2003;289(10):1278-1287.
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