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In Reply: Dr Emmett highlights the important point that odds ratios and relative risks are not equivalent, or nearly so, when the outcomes of interest in a cohort study are not rare. Using the equation of Zhang and Yu,¹ the relative risks (diuretic use vs nonuse on the first day of consultation) of in-hospital mortality and death or nonrecovery were 1.25 and 1.36, respectively.

Dr Tedesco is correct that the study sample was limited to those patients in whom nephrology consultation was requested. It is possible (probable, in fact) that consultation was not requested for some patients with rapid recovery of renal function. We stated that the results cannot be extrapolated to other clinical settings (including among individuals with more mild forms of ARF), although ARF prevention studies also suggest no benefit to diuretic therapy.²

Dr Unnikrishnan and colleagues are correct that the increase in mortality seen among patients treated . . . [Full Text of this Article]

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