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To the Editor: Drs Hu and Willett¹ state that "in 1908, Ignatowski produced atherosclerosis in rabbits with a diet high in cholesterol and saturated fat." Ignatowski is credited with having suggested that there could be a possible connection between foods rich in cholesterol and experimental atherosclerosis. But the credit for having produced atherosclerosis in rabbits in 1913 by feeding them a cholesterol-rich diet goes to Anichkov and Chalatov.² Their results were not accepted universally as being relevant to human disease since cholesterol is not a normal constituent of the rabbit's diet.

Shirley Siew, MD
Michigan State University
East Lansing

1. Hu FB, Willett WC. Optimal diets for prevention of coronary heart disease. JAMA. 2002;288:2569-2578. FREE FULL TEXT 2. Anichkov N, Chalatov S. Ueber experimentelle Choleserinsteatose: Ihre Bedeutung fur die Enstchung einer pathologischer Processen. Centrbl Allg Pathol Pathol Anat. 1913;24:1-9.

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289:1510.

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