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  Vol. 289 No. 12, March 26, 2003 TABLE OF CONTENTS
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Optimal Diets to Prevent Heart Disease—Reply

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In Reply: Dr McDougall's assertion that fish and omega-3 fatty acid intake is harmful to cardiac and general health runs contradictory to a large body of evidence from epidemiological studies and clinical trials reviewed in our article. In particular, omega-3 fatty acids are known to have potent triglyceride-lowering effects (the effects on total cholesterol are relatively small) and antiarrhythmia effects. More than a dozen epidemiologic studies have shown that higher consumption of fish is associated with lower risk of fatal CHD. In addition, clinical trials have shown that omega-3 fatty acids reduce risk of sudden death and total mortality. Although mercury contamination from some types of fish may attenuate the benefits of marine omega-3 fatty acids,1 this issue needs further investigation. In dietary practice, consumption of a variety of fish can minimize mercury exposure from fish.2

We agree with Dr Bryan that sodium reduction is an important means to reduce . . . [Full Text of this Article]



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