 |
 |

Reducing the Risk of Stroke
 |
 |
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
 |
 |
To the Editor: Dr Straus and colleagues1 stated that "the Antiplatelet Trialists' Collaboration [ATC]2 did not find that adding dipyridamole to aspirin resulted in significant benefit over the use of aspirin alone, but they noted that a single randomized trial found that the addition of extended-release dipyridamole to aspirin decreased the risk of death significantly." The ATC authors claimed that the results of this "single randomized trial" (ESPS-2),3 which demonstrated significant reduction in stroke risk, was inconsistent with preceding negative trials of dipyridamole plus aspirin for cardiovascular disease prevention and that its results may have arisen "largely or wholly by the play of chance."2
In fact, ESPS-2 was the only prospective, multicenter randomized trial that was adequately designed (2 x 2 factorial analysis) and adequately powered to determine the independent and additive efficacy of aspirin and (extended-release) dipyridamole. The number of patients and vascular events (including strokes) in ESPS-2 exceeded . . . [Full Text of this Article]
James M. Gebel, MD
Department of Neurology University of Pittsburgh Medical Center Pittsburgh, Pa
Louis R. Caplan, MD
Department of Neurology Beth Israel Medical Center Boston, Mass
CiteULike Connotea Del.icio.us Digg Reddit Technorati Twitter
What's this?
RELATED ARTICLES
Reducing the Risk of Stroke
Albert Fournier, Roxana Oprisiu, Michel Andrejak, Jean Michel Achard, and Leonardo Fernandez
JAMA. 2003;289(15):1927-1928.
EXTRACT
| FULL TEXT
Reducing the Risk of Stroke
Kamakshi Lakshminarayan and David C. Anderson
JAMA. 2003;289(15):1928.
EXTRACT
| FULL TEXT
Reducing the Risk of Stroke
Howard S. Kirshner
JAMA. 2003;289(15):1928.
EXTRACT
| FULL TEXT
Reducing the Risk of StrokeReply
Sharon E. Straus, Finlay A. McAlister, and Sumit R. Majumdar
JAMA. 2003;289(15):1929.
EXTRACT
| FULL TEXT
New Evidence for Stroke Prevention: Scientific Review
Sharon E. Straus, Sumit R. Majumdar, and Finlay A. McAlister
JAMA. 2002;288(11):1388-1395.
ABSTRACT
| FULL TEXT
|