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An Active, Potentially Treatable Disease Process?

Mike Mitka

JAMA. 2003;289:2197-2198.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Chicago—An age-old problem may not be an old-age phenomenon as conventional wisdom has believed.

The cardiology community has long assumed that aortic stenosis is a wear-and-tear, degenerative process caused, in part, by a heart beating for many decades. But research over the past few years suggests a different, more active, cause—lipoprotein deposits and inflammation of the aortic valve, with resulting calcification and ossification.

Electron beam tomography allows physicians to detect calcification (indicated by the arrow) of the aortic valve that separates the aorta (Ao) from the left ventricle (LV). (Reproduced with permission from Budoff MJ et al. Acad Radiol. 2002;9:1122-1127.) (Photo credit: Association of University Radiologists)

And if it is an active process, then medical therapy, such as statins or angiotensin-converting enzyme (ACE) inhibitors, may delay or possibly prevent clinical aortic valvular disease, even allowing patients to avoid valve replacement surgery, said Kevin D. O'Brien, MD, at . . . [Full Text of this Article]

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