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	Since this article does not have an abstract, we have provided the first 104 words of the full text and any section headings.

To the Editor: Dr Trinh and colleagues¹ concluded that ChIs have a "modest beneficial impact on neuropsychiatric and functional outcomes for patients with AD." The differences, in fact, were exceedingly small.

The most important point of view, though, is that of the caregivers. It would be of interest to know if there were data about whether they thought that these drugs provided benefit to their loved ones, or whether they themselves had any improvement in their quality of life. If not, then I would interpret these results as clinically insignificant.

Thomas E. Finucane, MD
Department of Medicine
Johns Hopkins Bayview Medical Center
Baltimore, Md

1. Trinh NH, Hoblyn J, Mohanty S, Yaffe K. Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis. JAMA. 2003;289:210-216. FREE FULL TEXT

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289:2359.

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