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To the Editor: Combination antiretroviral therapy (CART) can dramatically improve the prognosis of patients with human immunodeficiency virus (HIV), but 90% of infected individuals worldwide do not have access to these drugs.¹ Although generic drugs are now available in many countries at costs that are considerably lower than those of discounted proprietary agents, there have been anecdotal reports of generic antiviral medications that contain little or no active ingredients.^2-3 As part of a quality-assurance investigation, we analyzed the content of several generic and proprietary antiretroviral formulations containing the non-nucleoside reverse transcriptase inhibitor nevirapine.

Methods

Tablets containing nevirapine (alone or in combination with other antiretroviral agents) were obtained from 6 international sources, representing 4 countries and 3 manufacturers (Table 1). Medications were obtained in April 2002 from physicians from South Africa, Zambia, Lithuania, and Kenya who were attending an HIV educational training program at the National Institutes of Health in . . . [Full Text of this Article]

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