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Déjà Vu All Over Again?

Kristine Yaffe, MD

JAMA. 2003;289:2717-2719.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

More than 33% of women and 20% of men aged 65 and older will develop dementia during their lifetime.¹ With the aging of the US population, the number of individuals with Alzheimer disease (AD) and other forms of dementia is expected to quadruple over the next 50 years.² This projected exponential increase in the prevalence of dementia, along with the anticipated impact on families and society, highlights the imperative for developing preventive strategies. There is also increasing interest in preventing mild cognitive impairment (MCI), a cognitive and functional state in between normal aging and dementia, that frequently progresses to dementia.³

Estrogen therapy has been one of the most compelling potential strategies for prevention of dementia, primarily AD. Strong biological evidence supports the beneficial effects of estrogen on the brain including neurotrophic effects, reductions in -amyloid accumulation, enhanced neurotransmitter release and action, and protection against oxidative damage.^4-5 Estrogen . . . [Full Text of this Article]

Author Affiliations: Departments of Psychiatry, Neurology, and Epidemiology, University of California, San Francisco, and the San Francisco Veterans Affairs Medical Center, San Francisco.

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