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Lenore J. Launer, PhD

JAMA. 2003;289:2865-2867.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In this issue of THE JOURNAL, Aisen and colleagues¹ from the Alzheimer's Disease Cooperative Study (ADCS) report the results of a 1-year double-blind, placebo-controlled randomized trial designed to test whether 2 nonsteroidal anti-inflammatory drugs (NSAIDs), naproxen and rofecoxib, slowed cognitive decline in patients with mild to moderate Alzheimer disease (AD). These NSAIDs were tested separately against their own placebo, and the authors used several analytical strategies to test for an effect. The primary outcome measure (Alzheimer Disease Assessment Scale-cognitive subscale [ADAS-Cog] score, which measures the cognitive domains impaired in AD) showed no difference between the placebo and treatment groups with either of the NSAIDs. Similarly, the secondary outcomes (measures of activities of daily living, quality of life, and time to institutionalization or death) showed no evidence of a treatment effect.

NSAIDs were selected as a candidate drug for the treatment of AD based on the evidence . . . [Full Text of this Article]

Author Affiliation: Neuroepidemiology Section, Laboratory for Epidemiology, Demography, Biometry, National Institute on Aging, Bethesda, Md.

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