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Joan Stephenson, PhD

JAMA. 2003;289:2929.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Researchers from the United States and France have succeeded in growing mouse egg cells from both male and female embryonic stem cells in laboratory cultures. The report was published online on May 2 on the Web site of Science (http://www.sciencemag.org) and in print in the journal's May 23 issue.

A bright-field image shows structures resembling ovarian follicles, which arose from mouse embryonic stem cells that developed into egg cells in culture. Reprinted with permission from Science. 2003;300:1251-1256. Copyright 2003 American Association for the Advancement of Science. (Photo credit: K. Hübner and H. R. Schöler)

Previous efforts to coax cultured embryonic stem cells to develop into egg or sperm cells had been unsuccessful; the feat is the first demonstration that mammalian embryonic stem cells remain totipotent, or capable of developing into every cell type, even outside the body.

The investigators isolated a population of stem . . . [Full Text of this Article]

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