CLINICIAN'S CORNER
Sarcoidosis
Karl W. Thomas, MD;
Gary W. Hunninghake, MD
JAMA. 2003;289:3300-3303.
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INTRODUCTION
Sarcoidosis is a systemic inflammatory disease that occurs throughout the world and affects people of all races and ages. Despite years of study and many recent advances in diagnostic strategies, the etiology of sarcoidosis remains unknown. The disease is characterized pathologically by the presence of noncaseating granulomas in affected organs. These granulomas can occur with varying rates in any organ system, but most commonly are found in the lung and lymph nodes. Patients with sarcoidosis may be entirely asymptomatic or can have a wide range of constitutional and other nonspecific symptoms. The wide spectrum of affected patients, variability in organ involvement, absence of specific symptoms, and unidentified etiology combine to make sarcoidosis both a diagnostic and a therapeutic challenge.
An expert panel recently proposed adoption of standard diagnostic criteria for sarcoidosis to guide clinical evaluation and to promote standardization of . . . [Full Text of this Article]
Clinical Presentation and Diagnostic Evaluation
Natural History and Prognosis
Influence of Racial, Ethnic, and Genetic Factors on Disease Presentation and Prognosis
Etiology of Sarcoidosis
Approach to Treatment
Outlook
Author Affiliation: Department of Internal Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City (Drs Thomas and Hunninghake).
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