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Ginkgo and Memory
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To the Editor: Dr Solomon and colleagues1 found that an over-the-counter ginkgo supplement did not enhance memory in elderly individuals after 6 weeks of supplementation at the manufacturer's recommended dose and duration. The authors acknowledged that they did not conduct an independent laboratory analysis of the product. Unfortunately, quantitative analysis of the product is proprietary company information (Anne LaRusso, product manager, and David R. Morrison, director of scientific affairs, Boehringer Ingelheim; written communication, 2002). As a result, the exact quantity of the active ingredients remains unknown.
More importantly, even if the standardized quantities of active ingredients in the product were confirmed, the bioavailability and bioactivity of each ingredient are not equal.2 For example, a 6% terpene lactone concentration may contain a reproducible composition of ginkgolide A, B, C, or J, but these and other potentially active compounds (secondary metabolites3) may act synergistically or antagonistically in vivo.2 Therefore, product testing . . . [Full Text of this Article]
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