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Michael P. Busch, MD, PhD; Steven H. Kleinman, MD; George J. Nemo, PhD

JAMA. 2003;289:959-962.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

The blood supply in the United States and other developed countries has never been as safe as it is now. During the past several decades, there have been dramatic progressive reductions in the risk of transfusion-transmitted clinically significant blood-borne infections. This has been accomplished as a result of extensive research to characterize transfusion-transmitted pathogens, development of strategies to measure infection rates in blood donor and recipient populations, characterization of the dynamics of early viremia, and implementation of progressively more restrictive donor eligibility criteria and increasingly sensitive laboratory screening methods.

In addition, regulatory oversight by the US Food and Drug Administration (FDA) has been strengthened, resulting in enhanced quality assurance programs in blood collection and transfusion facilities. Pathogen reduction methods, already successfully applied to pooled plasma derivatives (eg, albumin, clotting factor concentrates, immunoglobulin preparations) are now in development . . . [Full Text of this Article]

Major Viral Infections and Impact of Nucleic Acid Testing

Emerging Infections

Impact of Safety Measures

Conclusions

Author Affiliations: Blood Centers of the Pacific and University of California, San Francisco, and Blood Systems Inc, Scottsdale, Ariz (Dr Busch); Westat Inc, Rockville, Md, and University of British Columbia, Victoria (Dr Kleinman); and National Heart, Lung, and Blood Institute, Bethesda, Md (Dr Nemo).

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