This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on ISI (4)  • Contact me when this article is cited  Related Content  • Related articles  • Similar articles in JAMA

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To the Editor: In their Research Letter, Dr Simon and colleagues reported a high percentage of trypsinogen mutations in patients with nonalcoholic (idiopathic) chronic pancreatitis.¹ However, the authors do not cite a number of previous studies of this relationship, some of which found a weaker association.^2-6 The 5 largest studies of the association of chronic idiopathic pancreatitis and trypsinogen mutations are shown in Table 1. We focused on the most common trypsinogen mutations, A16V, N29I, and R122H, as they were the only ones clearly shown to be disease associated.

Table appears in full text version. Table. Frequency of Mutations of Cationic Trypsinogen in Patients With Idiopathic Pancreatitis and Impact Factors of Journals

From Table 1, it appears that studies that evaluate more patients tend to find a lower percentage of trypsinogen mutations. The small "positive" studies, however, are more likely to be published in journals with higher impact factors. This appears to be an . . . [Full Text of this Article]

RELATED ARTICLES

Idiopathic vs Hereditary Pancreatitis
Jian-Min Chen and Claude Férec
JAMA. 2003;289(8):984-985.
EXTRACT | FULL TEXT  

Idiopathic vs Hereditary Pancreatitis
F. Ulrich Weiss, Peter Simon, Carsten Hohoff, Klaus Peter Zimmer, Wolfram Domschke, and Markus M. Lerch
JAMA. 2003;289(8):985.
EXTRACT | FULL TEXT  

Spontaneous and Sporadic Trypsinogen Mutations in Idiopathic Pancreatitis
Peter Simon, F. Ulrich Weiss, Klaus Peter Zimmer, Steven Rand, Bernd Brinkmann, Wolfram Domschke, and Markus M. Lerch
JAMA. 2002;288(17):2122.
EXTRACT | FULL TEXT