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  Vol. 289 No. 9, March 5, 2003 TABLE OF CONTENTS
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Estrogen Replacement and Risk of Alzheimer Disease

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To the Editor: Dr Zandi and colleagues1 found that HRT nonusers were significantly older than HRT users and had a 300% higher incidence of AD. Women with missing data on HRT use were even older than nonusers and had an additional 250% higher incidence of AD. Thus, it appears that these age differences were responsible for most of the increased incidence of AD. It is possible that at least some of the older women did not recall their HRT use simply because they were at the early stages of AD.

There may be other unmeasured selection biases among HRT users, who tend to be healthier than nonusers. Use of HRT is strongly associated with demographic and health-related factors.2 Initiation of HRT is associated with being encouraged by a physician and believing in the preventive efficacy of HRT.3 Many of these demographic, health issues, and prevention measures and beliefs are also . . . [Full Text of this Article]



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