You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT JAMA
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 289 No. 9, March 5, 2003 TABLE OF CONTENTS
  JAMA
  •  Online Features
  Letters
 This Article
 •Full text
 •PDF
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Contact me when this article is cited
 Related Content
 •Related articles
 •Similar articles in JAMA
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

Estrogen Replacement and Risk of Alzheimer Disease—Reply

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In Reply: We agree with Dr Smith and colleagues that there are a variety of direct and indirect mechanisms by which estrogen and estrogen-containing hormone therapy could affect brain function or be associated with neurologic disease. The pathogenic relevance of modest elevations in plasma gonadotropin concentrations observed in women (but not men) with AD1 is open to speculation and, of course, to experimental investigation and empirical validation.

Dr Rosenberg makes the point that recent randomized trials document increased risk of coronary heart disease for users of estrogen/progestin therapy, a finding that contrasts with benefit anticipated on the basis of several earlier observational studies. As Rosenberg notes, different results likely reflect the healthy user bias in observational studies, ie, the tendency for women who choose to take hormone therapy to be healthier and more highly educated. We discussed possible biases, confounders, and other limitations of the study by Zandi et al.2 . . . [Full Text of this Article]



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

RELATED ARTICLES

Estrogen Replacement and Risk of Alzheimer Disease
Mark A. Smith, George Perry, Craig S. Atwood, and Richard L. Bowen
JAMA. 2003;289(9):1100.
EXTRACT | FULL TEXT  

Estrogen Replacement and Risk of Alzheimer Disease
Amnon Lahad and Lev Ishay
JAMA. 2003;289(9):1100-1101.
EXTRACT | FULL TEXT  

Estrogen Replacement and Risk of Alzheimer Disease
J. Galen Buckwalter, Diana B. Petitti, and Valerie C. Crooks
JAMA. 2003;289(9):1101.
EXTRACT | FULL TEXT  

Estrogen Replacement and Risk of Alzheimer Disease
Lynn Rosenberg
JAMA. 2003;289(9):1101.
EXTRACT | FULL TEXT  

Estrogen Replacement and Risk of Alzheimer Disease—Reply
Peter P. Zandi and John C. S. Breitner
JAMA. 2003;289(9):1101-1102.
EXTRACT | FULL TEXT  

Hormone Replacement Therapy and Incidence of Alzheimer Disease in Older Women: The Cache County Study
Peter P. Zandi, Michelle C. Carlson, Brenda L. Plassman, Kathleen A. Welsh-Bohmer, Lawrence S. Mayer, David C. Steffens, John C. S. Breitner, and for the Cache County Memory Study Investigators
JAMA. 2002;288(17):2123-2129.
ABSTRACT | FULL TEXT  






HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 2003 American Medical Association. All Rights Reserved.