This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related articles  • Similar articles in JAMA  Social Bookmarking   What's this?

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In Reply: We agree with Dr Smith and colleagues that there are a variety of direct and indirect mechanisms by which estrogen and estrogen-containing hormone therapy could affect brain function or be associated with neurologic disease. The pathogenic relevance of modest elevations in plasma gonadotropin concentrations observed in women (but not men) with AD¹ is open to speculation and, of course, to experimental investigation and empirical validation.

Dr Rosenberg makes the point that recent randomized trials document increased risk of coronary heart disease for users of estrogen/progestin therapy, a finding that contrasts with benefit anticipated on the basis of several earlier observational studies. As Rosenberg notes, different results likely reflect the healthy user bias in observational studies, ie, the tendency for women who choose to take hormone therapy to be healthier and more highly educated. We discussed possible biases, confounders, and other limitations of the study by Zandi et al.² . . . [Full Text of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLES

Hormone Replacement Therapy and Incidence of Alzheimer Disease in Older Women: The Cache County Study
, , , , , , , and
JAMA. ;288():2123-2129.
FULL TEXT  

Estrogen Replacement and Risk of Alzheimer Disease
, , , and
JAMA. ;289():1100-1100.
FULL TEXT  

Estrogen Replacement and Risk of Alzheimer Disease
and
JAMA. ;289():1100-1101.
FULL TEXT  

Estrogen Replacement and Risk of Alzheimer Disease
, , and
JAMA. ;289():1101-1101.
FULL TEXT  

Estrogen Replacement and Risk of Alzheimer Disease

JAMA. ;289():1101-1101.
FULL TEXT  

Estrogen Replacement and Risk of Alzheimer Disease--Reply
and
JAMA. ;289():1101-1102.
FULL TEXT