This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (7)  • Contact me when this article is cited  Related Content  • Related letter  • Related articles  • Similar articles in JAMA  Topic Collections  • Bacterial Infections  • Pediatrics  • Pediatrics, Other  • Renal Diseases  • Acute Renal Failure  • Gastroenterology  • Gastrointestinal Diseases  • Infectious Diseases  • Alert me on articles by topic  Social Bookmarking   What's this?

Richard L. Siegler, MD

JAMA. 2003;290:1379-1381.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Postdiarrheal Shiga toxin–mediated hemolytic uremic syndrome (HUS) is the major cause of acute renal failure in infants and young children¹ and is a substantial cause of mortality and chronic morbidity. Adolescents who develop postdiarrheal HUS fare as well as younger children² but adults, especially elderly individuals, experience a higher incidence of death and disability.³

There are no treatments of proven value, and care during the acute phase of the illness, which is merely supportive, has not changed substantially during the past 30 years. Although US mortality for infants and young children decreased markedly following the widespread availability of pediatric dialysis units and intensive care facilities, 3% to 5% of patients who develop HUS still die during the acute phase.¹ An equal number have severe brain damage or end-stage renal disease (ESRD)^{1, 4} and require chronic renal replacement therapy (dialysis or renal transplantation) within the first few years. . . . [Full Text of this Article]

Author Affiliations: Division of Nephrology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED LETTER

Farming and Slaughterhouse Practices to Reduce Meat-Borne Disease
Mary Ellen Walker
JAMA. 2003;290(24):3193-3194.
EXTRACT | FULL TEXT  

RELATED ARTICLES

Effect of an Oral Shiga Toxin–Binding Agent on Diarrhea-Associated Hemolytic Uremic Syndrome in Children: A Randomized Controlled Trial
Howard Trachtman, Avital Cnaan, Erica Christen, Kathleen Gibbs, Sanyi Zhao, David W. K. Acheson, Robert Weiss, Frederick J. Kaskel, Adrian Spitzer, and Gladys H. Hirschman
JAMA. 2003;290(10):1337-1344.
ABSTRACT | FULL TEXT  

Long-term Renal Prognosis of Diarrhea-Associated Hemolytic Uremic Syndrome: A Systematic Review, Meta-analysis, and Meta-regression
Amit X. Garg, Rita S. Suri, Nick Barrowman, Faisal Rehman, Doug Matsell, M. Patricia Rosas-Arellano, Marina Salvadori, R. Brian Haynes, and William F. Clark
JAMA. 2003;290(10):1360-1370.
ABSTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Subtypes of the Plasmid-Encoded Serine Protease EspP in Shiga Toxin-Producing Escherichia coli: Distribution, Secretion, and Proteolytic Activity
Brockmeyer et al.
Appl. Environ. Microbiol. 2007;73:6351-6359.
ABSTRACT | FULL TEXT  

Farming and Slaughterhouse Practices to Reduce Meat-Borne Disease
Walker
JAMA 2003;290:3193-3194.
FULL TEXT