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To the Editor: Several epidemiologic studies have found an association between the presence of an apolipoprotein E (APOE) 4 allele and increased risk for Alzheimer disease (AD). Although 2 brain imaging studies of middle-aged and elderly individuals have found that the 4 allele is associated with an AD-like pattern on positron emission tomogrophy (PET) brain scans,^1-2 we are not aware of any study has that has examined this association in young individuals.

Methods

We recruited 18 college-age individuals who were without significant medical problems, as determined by medical, neurologic, psychiatric, and neuropsychological evaluations, as well as by magnetic resonance imaging of the brain. After obtaining informed consent, we determined the 4 allele status of each individual. After providing informed consent, all participants waived their right to be informed of these results. Participants then underwent resting H₂¹⁵O PET scans of the brain to determine resting relative cerebral blood flow . . . [Full Text of this Article]

Nikolaos Scarmeas, MD
Department of Neurology

Christian G. Habeck, PhD; Yaakov Stern, PhD
Cognitive Neuroscience Division
Taub Institute for Research in Alzheimer's Disease and the Aging Brain
College of Physicians and Surgeons of Columbia University
New York, NY

Karen E. Anderson, MD
Department of Psychiatry
University of Maryland
Baltimore

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