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Sex Ratios in Families With BRCA Mutations—Reply
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In Reply: We agree with Dr Mealiffe that a sex-ratio ascertainment bias does exists in our cohort of families. As he points out, by selecting families with at least 3 cases of breast and/or ovarian cancer, we also selected families with at least 3 females. Less obvious sources of bias may also have been present, as Mealiffe suggests. Indeed, we have some evidence of a modest sex-ratio ascertainment bias present in our cohort of families with breast and/or ovarian cancer. A slight excess of male births is well documented in the general population. For example, according to the Spanish National Statistics Institute,1 48.6% of all Spanish newborns were female in the year 2001. In contrast with the cohort we described in our article, we observed a similar sex ratio (47.1% female births; 328 females vs 368 males) when considering as a whole 45 HNPCC pedigrees ascertained according to Amsterdam criteria . . . [Full Text of this Article]
Miguel de la Hoya, PhD;
Juan M Fernández, BS;
Alicia Tosar, PhD;
Javier Godino, BS;
Ana Sánchez de Abajo, BS;
José A Vidart, MD, PhD;
Pedro Pérez-Segura, MD, PhD;
Eduardo Díaz-Rubio, MD, PhD;
Trinidad Caldés, PhD
Molecular Oncology Unit
Hospital Clínico San Carlos
Madrid, Spain
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