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To the Editor: Ozone, an oxidant of photochemical smog, is known to cause a variety of respiratory effects, including diminished lung function, exacerbation of respiratory symptoms, and inflammation of airways.¹ To date, lung inflammation has been measured only invasively, by analysis of bronchoalveolar lavage fluid obtained from adults exposed to relatively high concentrations of ozone while exercising.^2-3 We used exhaled nitric oxide⁴ to measure the relationship between ambient ozone levels and inflammation of airways.

Methods

After parents had given their written informed consent, we examined 72 children, aged 6.5 to 15 years, attending 1 of 6 summer camps in rural southern Belgium. All children were healthy and free of asthma. Ambient ozone concentrations were continuously monitored at each camp during the time of our study (Ozone Analyzer Model 427, Signal Instrument Company, Faringdon, England) and checked for accuracy with data from the nearest local monitoring stations, which also measured other gaseous . . . [Full Text of this Article]

Marc Nickmilder, PhD; Sylviane Carbonnelle, MD; Claire de Burbure, MD; Alfred Bernard, PhD
Unit of Toxicology
Catholic University of Louvain
Brussels, Belgium