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Tracy Hampton, PhD

JAMA. 2003;290:2655.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Changes in the expression of imprinted genes—genes differentially expressed depending on whether they are inherited from the mother or father—have been linked to a variety of human malignancies. Scientists from the National Cancer Institute, studying the phenomenon in mice, have identified some of the dramatic differences between the effects of maternal and paternal genomes in work that provides insight on how factors other than genetic mutations can cause cancer (published October 27 in the online edition of the Proceedings of the National Academy of Sciences of the United States of America; http://www.pnas.org).

An osteosarcoma formed from cells that contain only the paternal genome. Cells containing only the maternal genome or both parental genomes did not form tumor cells. (Photo credit: L. Hernandez/National Cancer Institute)

The researchers cultured fibroblast cells taken from mouse embryos engineered to have a genome expressing solely maternal or paternal genes. Cells . . . [Full Text of this Article]

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