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In Reply: In response to Dr Kida, Hart et al¹ found female sex to be an independent predictor of stroke in individuals with atrial fibrillation (adjusted relative risk for stroke, 1.6 [P = .01]; and for disabling or fatal stroke, 1.8 [P = .03]). Thus, their results are similar to ours. These authors reported that the disparity in absolute rates of stroke between women and men was smaller in the subgroup aged 75 years or older, which may not be surprising given the lower event rates in younger individuals and the sex-related differences in risk-factor burden.

We have performed an additional analysis to address the point raised by Kida, adding an interaction term for sex and age (75 years) to the multivariable model for stroke. The sex x age interaction term was not statistically significant (P = .34), suggesting that age does not significantly modify the . . . [Full Text of this Article]

Thomas J. Wang, MD; Joseph M. Massaro, PhD; Emelia J. Benjamin, MD, ScM

RELATED ARTICLE

Age and Sex as Independent Risk Factors for Stroke Among Patients With Atrial Fibrillation
Yujiro Kida
JAMA. 2003;290(22):2937.
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