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Scott M. Grundy, MD, PhD

JAMA. 2003;290:3000-3002.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In this issue of THE JOURNAL, Sesso and colleagues¹ report a positive relationship between increased serum levels of C-reactive protein and the risk for development of incident hypertension in participants of the Women's Health Study. A total of 20 525 women were followed up prospectively for a median of 7.8 years, during which time approximately one fourth of the women acquired elevated blood pressure; those with higher levels of C-reactive protein were more likely to develop hypertension. C-reactive protein levels in the upper ranges of the normal distribution (high-normal levels of C-reactive protein) are widely believed to reflect a state of low-grade chronic inflammation; therefore, the association between higher C-reactive protein levels and new-onset hypertension led Sesso et al¹ to suggest that hypertension may be an inflammatory disease.

The term inflammation is applied by Sesso et al¹ because higher levels of C-reactive protein are thought to . . . [Full Text of this Article]

Author Affiliations: Departments of Clinical Nutrition, Internal Medicine, and the Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas.

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