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To the Editor: Dr Chiasson and colleagues¹ reported that treatment with acarbose was associated with a significant reduction in the incidence of cardiovascular disease and hypertension among patients with impaired glucose tolerance (IGT). The authors claimed that their study was the first to report these results. In fact, however, my colleagues and I have previously reported that acarbose and glibenclamide significantly reduced blood pressure levels among patients with hypertension and type 2 diabetes.²

Julian H. Rosenthal, MD
Department of Medicine
Dartmouth Medical School
Hanover, NH

1. Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M, for the STOP-NIDDM trial research group. Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA. 2003;290:486-494. FREE FULL TEXT 2. Rosenthal J, Mauersberger H. Effects on blood pressure of the -glucosidase inhibitor acarbose compared with the insulin enhancer glibenclamide in patients with hypertension and type 2 diabetes mellitus. Clin Drug Invest. 2002;22:695-701. FULL TEXT

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290:3066.

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