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To the Editor: I question whether the legend in Figure 4 of the study by Dr Chiasson and colleagues¹ is accurate. A total of 1368 participants were included in the overall analysis. According to the authors' Table 1 , 702 of these participants (51%) had hypertension at baseline. Thus, at the time of study entry, the remaining 666 participants were apparently free of hypertension. Yet 1368 participants are listed as "at risk" on the Kaplan-Meier plot of the effect of acarbose on the probability of remaining free of hypertension. I trust that the log-rank and Cox proportional model statistical tests for treatment effect were actually performed on the 666 participants who were free of hypertension at baseline.

The authors noted that "although all those factors (ie, blood pressure, response to oral glucose tolerance test, body weight, waist circumference, body mass index, and serum triglyceride level) could explain, in part, the . . . [Full Text of this Article]

Claude M. Bridges, MD
Department of Internal Medicine
Mayo Clinic
Rochester, Minn

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