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In Reply: We thank Dr Rosenthal for bringing to our attention his finding that acarbose had a significant blood pressure–lowering effect in patients with hypertension and type 2 diabetes.¹ We did not claim that we were the first to demonstrate that acarbose could reduce hypertension. We claim that our trial is the first prospective study to find that acarbose can decrease the risk of new cases of cardiovascular disease and new cases of hypertension in patients with IGT.² As far as we know, that is still true. We also found that acarbose could reduce both systolic and diastolic blood pressure in this group of patients, an observation consistent with Rosenthal's observation in patients with hypertension and diabetes.

In response to Mr Kaiser and Dr Sawicki, our analysis was based on the results of the modified ITT sample (n = 1368).² In that sample, 49 patients in the placebo group and . . . [Full Text of this Article]

Jean-Louis Chiasson, MD; Robert G. Josse, MBBS; Ramon Gomis, MD; Markolf Hanefeld, DSC; Avraham Karasik, MD; Markku Laakso, MD for The STOP-NIDDM Trial Research Group

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