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CLINICIAN'S CORNER
A 50-Year-Old Man With Hepatitis C and Cirrhosis Needing Liver Transplantation
Douglas W. Hanto, MD, PhD, Discussant
JAMA. 2003;290:3238-3246.
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INTRODUCTION
DR SHIP: Mr G is a 50-year-old man who has had liver disease for about 12 years. He lives near Boston with his wife and children and is a partner in a small industrial firm. He has managed care insurance.
During a routine life insurance evaluation in 1991, Mr G was found to have abnormal liver function test results and was diagnosed with non-A, non-B hepatitis. Liver biopsy showed mild periportal inflammation. In 1995, he was found to have antibodies to hepatitis C. He was treated with interferon and ribavirin but did not improve. A liver biopsy in 2001 revealed grade II to III inflammation, stage IV fibrosis. He was subsequently treated with pegylated interferon and ribavirin and again did not improve. In 2001, he developed transient ascites and encephalopathy, with unsteady gait and forgetfulness. In 2002, Mr G bled from . . . [Full Text of this Article]
MR G: HIS VIEW
AT THE CROSSROADS: QUESTIONS FOR DR HANTO
Epidemiology Indications and Contraindications Pretransplant Evaluation, Options, and Listing Medical Management of Hepatitis C and Cirrhosis Liver Transplantation Immunosuppression, Infections, and Surgical Complications After Liver Transplantation Prognosis After Liver Transplantation Recommendations for Mr G
QUESTIONS AND DISCUSSION
Author Affiliation: Dr Hanto is Chief, Division of Transplantation, Department of Surgery, Beth Israel Deaconess Medical Center, and the Lewis Thomas Professor of Surgery, Harvard Medical School, Boston, Mass.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
A 50-Year-Old Man With Hepatitis C and Cirrhosis Needing Liver Transplantation, 18 Months Later
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JAMA 2005;293:2027-2027.
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