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  Vol. 290 No. 24, December 24/31, 2003 TABLE OF CONTENTS
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Evaluating and Optimizing Outcomes of Surgery for Endocarditis

David T. Durack, MB, DPhil

JAMA. 2003;290:3250-3251.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The mortality rate for infective endocarditis remains high—too high. In the preantibiotic era, death was inevitable for anyone unfortunate enough to develop this disease. Penicillin changed this dismal picture. By 1951, based on more than 1000 cases of endocarditis compiled from several reports, Hunter1 estimated that the overall cure rate was about 70%. A half-century later, despite the advent of valve replacement surgery and the development of many more antibiotics, the "global cure rate" for infective endocarditis remains about the same. For example, Hasbun et al2 recently reported a 6-month survival rate of 74% among 513 patients with endocarditis in the United States. Similarly, for 208 patients in England the cure rate at 6 months was 73%.3 Mortality in a large tertiary-care hospital in the United States was about 35%.4 When more favorable rates have been reported, for example from France by Hoen et al,5 . . . [Full Text of this Article]

Author Affiliation: Department of Medicine, Duke University, Durham, and BD Technologies, Triangle Park, NC.



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RELATED ARTICLE

Impact of Valve Surgery on 6-Month Mortality in Adults With Complicated, Left-Sided Native Valve Endocarditis: A Propensity Analysis
Holenarasipur R. Vikram, Joan Buenconsejo, Rodrigo Hasbun, and Vincent J. Quagliarello
JAMA. 2003;290(24):3207-3214.
ABSTRACT | FULL TEXT  


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

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Sy et al.
Circ Cardiovasc Qual Outcomes 2009;2:469-474.
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Subclinical Brain Embolization in Left-Sided Infective Endocarditis: Results From the Evaluation by MRI of the Brains of Patients With Left-Sided Intracardiac Solid Masses (EMBOLISM) Pilot Study
Cooper et al.
Circulation 2009;120:585-591.
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Mitral Valve Infective Endocarditis: Benefit of Early Operation and Aggressive Use of Repair.
Shang et al.
Ann. Thorac. Surg. 2009;87:1728-1734.
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Infective endocarditis in children: native valve preservation is frequently possible despite advanced clinical disease
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The Impact of Valve Surgery on 6-Month Mortality in Left-Sided Infective Endocarditis
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Predictors of Death and Impact of Surgery in Staphylococcus aureus Infective Endocarditis
Remadi et al.
Ann. Thorac. Surg. 2007;83:1295-1302.
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