This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related articles  • Similar articles in JAMA  Topic Collections  • Pediatrics  • Adolescent Medicine  • Substance Abuse/ Alcoholism  • Alert me on articles by topic  Social Bookmarking   What's this?

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In Reply: Dr Anand raises 2 issues in epidemiological research on the etiology of substance abuse.

First, he suggests that the models tested by Lynskey et al¹ were misspecified. Assuming that administration of opiates or other drugs to mothers at the time of delivery does increase the risk of drug addiction in offspring, does the omission of this factor in the analysis of Lynskey et al affect their conclusions in any way? I agree with Anand that the conclusions of Lynskey et al are not invalidated by the lack of attention to perinatal exposure to obstetric pain medication at the time of delivery. Both twins were similarly exposed to the putative perinatal causal factor. In a twin design, perinatal experiences are part of the shared influences that are held constant for subjects.

The second issue is how important a risk factor for drug addiction in offspring is giving drugs to . . . [Full Text of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLES

Early Exposure to Marijuana and Risk of Later Drug Use
Joshua G. Schier, Lewis S. Nelson, and Robert S. Hoffman
JAMA. 2003;290(3):329.
EXTRACT | FULL TEXT  

Early Exposure to Marijuana and Risk of Later Drug Use
Peter Cummings
JAMA. 2003;290(3):329.
EXTRACT | FULL TEXT  

Early Exposure to Marijuana and Risk of Later Drug Use
John Macleod, Matthew Hickman, and George Davey Smith
JAMA. 2003;290(3):329-330.
EXTRACT | FULL TEXT  

Early Exposure to Marijuana and Risk of Later Drug Use
K. J. S. Anand
JAMA. 2003;290(3):330.
EXTRACT | FULL TEXT  

Early Exposure to Marijuana and Risk of Later Drug Use—Reply
Michael T. Lynskey, Dixie J. Statham, Nicholas G. Martin, Andrew C. Heath, Kathleen K. Bucholz, Pamela A. F. Madden, Elliot C. Nelson, and Wendy S. Slutske
JAMA. 2003;290(3):330-331.
EXTRACT | FULL TEXT  

Escalation of Drug Use in Early-Onset Cannabis Users vs Co-twin Controls
Michael T. Lynskey, Andrew C. Heath, Kathleen K. Bucholz, Wendy S. Slutske, Pamela A. F. Madden, Elliot C. Nelson, Dixie J. Statham, and Nicholas G. Martin
JAMA. 2003;289(4):427-433.
ABSTRACT | FULL TEXT