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Risk of Multiple Sclerosis After Optic Neuritis
Commentary by Leonard A. Levin, MD, PhD;
and Simmons Lessell, MD
JAMA. 2003;290(3):403-404.
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ARCHIVES OF OPHTHALMOLOGY
High- and Low-Risk Profiles for the Development of Multiple Sclerosis Within 10 Years After Optic Neuritis: Experience of the Optic Neuritis Treatment Trial
The Optic Neuritis Study Group
Objective To identify factors associated with a high and low risk of developing multiple sclerosis after an initial episode of optic neuritis.
Methods Three hundred eighty-eight patients who experienced acute optic neuritis between July 1, 1988, and June 30, 1991, were followed up prospectively for the development of multiple sclerosis. Consenting patients were reassessed after 10 to 13 years.
Results The 10-year risk of multiple sclerosis was 38% (95% confidence interval, 33%-43%). Patients (160) who had 1 or more typical lesions on the baseline magnetic resonance imaging (MRI) scan of the brain had a 56% risk; those with no lesions (191) had a 22% risk (P<.001, . . . [Full Text of this Article]
Author Affiliations: Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison (Dr Levin), and Neuro-Ophthalmology Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Mass (Dr Lessell).
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