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Blood Lead Levels and Hypertension
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To the Editor: Although Dr Nash and colleagues1 generally avoided causal language in characterizing their observed association between blood lead levels and blood pressure in postmenopausal women, they nevertheless concluded that "these results demonstrate effects of lead" and called for "continued efforts to reduce lead levels." They did not state, however, how this might be accomplished. Because the principal source of lead for postmenopausal women is from their own skeletons, a high calcium intake would be a simple and obvious way to reduce resorptive release of lead into the blood. Even so, it is not clear that preventing an increase in blood lead levels, by itself, would prevent an increase in blood pressure.
Blood lead levels were extraordinarily low among the postmenopausal participants that Nash et al analyzed. The slight increases that they observed do not prove a toxic effect of lead; instead, this reflects increased mobilization of calcium from . . . [Full Text of this Article]
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