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Ernest C. Lee, MD, MPH

JAMA. 2003;290:659-662.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Chemical warfare has existed for millennia. As far back as 1000 BC, the Chinese used arsenical smoke as a weapon.¹ In the last century, chemical agents have been used in warfare on numerous occasions, from World War I to the Iran-Iraq conflict.² The world remains vulnerable to the deliberate use of chemical agents as weapons of mass destruction. Chemical attacks can be delivered with almost any type of conventional ballistic weapon, spray device, or by nontraditional means, such as that used by the Aum Shinrikyo religious cult to launch 2 attacks in public places in Japan by using sarin gas. The first attack occurred in Matsumoto, Japan, in June 1994.³ The second attack occurred in a Tokyo subway in March 1995.⁴ Terrorists involved in this attack carried diluted sarin solution in plastic bags into subway trains and punctured the bags with sharpened umbrella . . . [Full Text of this Article]

Sarin Toxicology

Mechanisms of Acute Toxicity

Exposure Variables and Toxicokinetics

Detection, Acute Clinical Manifestations, and Diagnosis

Prehospital Management, Triage, and Treatment

Historical and Public Health Perspective

Conclusion

Author Affiliation: Harvard Medical School, Boston, Mass.

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