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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To the Editor: We wish to raise some methodological concerns about the article by Dr Al-Khatib and colleagues.¹

Although the authors described a MEDLINE search, they did not provide a critical summary of published reports of drugs affecting the QT interval. Similarly, they did not include information from pharmacovigilance or postmarketing databases. Rather, their main table of results is based on an opinion survey whose methods and results were not presented.

Thus, we believe that several of their conclusions are unwarranted. For instance, the authors categorize sertraline's "potential . . . for causing QT prolongation" as "possible in high-risk patients." Yet there are no published data documenting that sertraline treatment is associated with QT prolongation or torsades de pointes in any high-risk patient population. Furthermore, in a double-blind, placebo-controlled clinical trial, Glassman et al² reported that sertraline was not associated with a risk of QT prolongation or torsades de pointes . . . [Full Text of this Article]

John A. Gillespie, MD; Cathryn M. Clary, MD
Pfizer Inc
New York, NY

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