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Cardiovascular Effects of Ephedra—Reply
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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In Reply: In response to Dr Krantz, we have previously reported that individuals with structural heart disease have baseline QTc intervals elevated to 413 milliseconds if they have left ventricular hypertrophy, 423 milliseconds if they have had a recent myocardial infarction, 438 milliseconds if they have dilated cardiomyopathy, and up to 460 milliseconds during an acute myocardial infarction. Thus, we agree with Krantz that these patients would be at enhanced risk of exceeding 500 milliseconds with the degree of QTc interval increase we had shown in our healthy sample.1-2
Dr Ness points out that these dietary weight loss products contain multiple ingredients, several of which may alter blood pressure. It is disturbing that the amount of goldenseal and Siberian ginseng in the product cannot be known. I also agree with Ness that just because ephedra is now banned by the Food and Drug Administration, this does not mean that a . . . [Full Text of this Article]
C. Michael White, PharmD
cmwhite{at}harthosp.org
University of Connecticut School of Pharmacy
Storrs
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