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To the Editor: Dr Chaitman and colleagues¹ did not present detailed safety data. In particular, we would be interested in knowing the effect ranolazine has on kidneys, liver, blood cells, or metabolism, as well as on quality of life and hospital admission rates. Furthermore, the authors reported that 30% to 41% of subjects stopped taking ranolazine, but they did not present their subsequent clinical events. The fate of these individuals is critical in assessing the safety of this drug.

Christoph Pechlaner, MD
christoph.pechlaner@uibk.ac.at
Innsbruck University Hospital
Innsbruck, Austria

Christian Wiedermann, MD
General Hospital of Bolzano
Bolzano, Italy

1. Chaitman BR, Pepine CJ, Parker JO, et al. Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. JAMA. 2004;291:309-316. FREE FULL TEXT

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291:1959.

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