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In Reply: In response to Dr Frieden and colleagues, we point out that the prevalences of congenital anomalies in the group treated with CART and the control group were not significantly different from one another (5.6% vs 1.7%, P = .09), whereas a significant difference was found in the prevalence of hemangiomas (4.2% vs 0.3%, P = .02). We selected a contemporary control group exposed to nonteratogenic drugs because, considering the importance of this therapy during pregnancy, a contemporary HIV-positive group not exposed to retroviral drugs was not available. Our 3 cases of hemangioma were found in 3 male infants, of whom only 1 was born prematurely (gestational age, 36 weeks). The case from among the control group was a female infant born at term of pregnancy.

We also stress the difference between head and midline small and large haemangiomas in noncommon sites. No transitory or small-sized hemangiomas were included . . . [Full Text of this Article]

Marco De Santis, MD; Anna Franca Cavaliere, MD; Alessandro Caruso, MD
Telefono Rosso—Teratology Information Service
Department of Obstetrics and Gynaecology

Paola Villa, MD
Department of Obstetrics and Gynaecology

Enrica Tamburrini, MD; Roberto Cauda, MD
Department of Infectious Disease

Carlo Fundaro, MD; Orazio Genovese, MD
Department of Pediatrics
Catholic University of the Sacred Heart
Rome, Italy

RELATED LETTER

Hemangiomas and Other Congenital Malformations in Infants Exposed to Antiretroviral Therapy In Utero
Marco De Santis, Anna Franca Cavaliere, Alessandro Caruso, Paola Villa, Enrica Tamburrini, Roberto Cauda, Carlo Fundaro, and Orazio Genovese
JAMA. 2004;291(3):305.
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RELATED ARTICLE

Combined Antiretroviral Therapy During Pregnancy and Risk of Congenital Malformations
Ilona J. Frieden, Anita N. Haggstrom, Charles McCulloch, Beth Drolet, Nancy B. Esterly, Maria C. Garzon, Anne W. Lucky, Eulalia Baselga, and Sheila F. Friedlander
JAMA. 2004;291(16):1961-1962.
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