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In Reply: In response to Dr Aguirre and colleagues, we have analyzed the proportion of patients taking aspirin or other antiplatelet agents in the 2 treatment groups. As would be expected from randomization of a large number of patients, there was no imbalance: 49.85% of those in the high-dose group vs 50.15% of those in the low-dose group were taking these medications at baseline (P = .71), and this did not change during the course of the study.

Dr Wald essentially reiterates calculations that we provided in the "Comment" section of our article, showing that, among North American patients with stroke, after folate fortification of the grain supply,¹ for the combination of 25 mg B₆, 0.4 mg B₁₂, and 2.5 mg folic acid, the estimated treatment effect on risk of ischemic stroke, coronary heart disease, or death was a 3% decrease (95% CI, –16% to 12%). Thus, . . . [Full Text of this Article]

J. David Spence, MD; James F. Toole, MD; Lloyd E. Chambless, PhD; Chin-Hua Wang, PhD; Meir Stampfer, MD, DrPH; L. Creed Pettigrew, MD, MPH; Virginia J. Howard, MSPH; Elizabeth G. Sides, MEd
esides@wfubmc.edu

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