 |
|
Helicobacter pylori Infection and Gastric Cancer—For Want of More Outcomes
Julie Parsonnet, MD;
David Forman, PhD
JAMA. 2004;291:244-245.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
In 1994, Helicobacter pylori was declared a type 1 carcinogen—a definite cause of human cancer—by the International Agency for Research on Cancer (IARC).1 This conclusion, which was based largely on epidemiological data that were later substantiated,2 left behind unsettling questions. First, some latent concern lingered that H pylori was merely a marker for other exposures. Despite subsequent studies in animals, humans, and tissue cultures indicating plausible mechanisms for H pylori–induced carcinogenesis, naysayers have clung to the small, residual probability that H pylori is merely a confounder for the true cause of disease. Because H pylori infection is so closely linked to socioeconomic status, such confounders are not difficult to find.
More important, however, the IARC evaluation left a dilemma. The organization provided no recommendations on how knowledge of a causal association between H pylori infection and cancer should inform clinical or public health . . . [Full Text of this Article]
Author Affiliations: Departments of Medicine and Health Research and Policy, Stanford University, Stanford, Calif (Dr Parsonnet); and Unit of Epidemiology and Health Services Research, Medical School, University of Leeds, Leeds, England (Dr Forman).
RELATED LETTERS
Dietary Risk Factors for Gastric Carcinoma
John H. Weisburger
JAMA. 2004;291(13):1564.
EXTRACT
| FULL TEXT
Dietary Risk Factors for Gastric Carcinoma—Reply
David Forman and Julie Parsonnet
JAMA. 2004;291(13):1564.
EXTRACT
| FULL TEXT
RELATED ARTICLE
Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of China: A Randomized Controlled Trial
Benjamin Chun-Yu Wong, Shiu Kum Lam, Wai Man Wong, Jian Shun Chen, Ting Ting Zheng, Rui E. Feng, Kam Chuen Lai, Wayne Hsing Cheng Hu, Siu Tsan Yuen, Suet Yi Leung, Daniel Yee Tak Fong, Joanna Ho, Chi Kong Ching, and Jun Shi Chen
JAMA. 2004;291(2):187-194.
ABSTRACT
| FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Effect of Helicobacter pylori Infection Combined with CagA and Pepsinogen Status on Gastric Cancer Development among Japanese Men and Women: A Nested Case-Control Study.
Sasazuki et al.
Cancer Epidemiol. Biomarkers Prev. 2006;15:1341-1347.
ABSTRACT
| FULL TEXT
Host-Environment Interactions: Their Impact on Progression from Gastric Inflammation to Carcinogenesis and on Development of New Approaches to Prevent and Treat Gastric Cancer
Wu et al.
Cancer Epidemiol. Biomarkers Prev. 2005;14:1878-1882.
ABSTRACT
| FULL TEXT
Dietary Risk Factors for Gastric Carcinoma
Weisburger
JAMA 2004;291:1564-1564.
FULL TEXT
Does Eradication of H. pylori Prevent Gastric Cancer?
JWatch Infect. Diseases 2004;2004:4-4.
FULL TEXT
|
