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David R. Nalin, MD; Norbert Hirschhorn, MD; William Greenough III, MD; George J. Fuchs, MD; Richard A. Cash, MD

JAMA. 2004;291:2632-2635.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Demonstration of the benefits of oral therapy for cholera in 1968¹ soon led to application of the method to all forms of infectious diarrheal diseases.² The original oral rehydration solution (ORS) formulation developed by the World Health Organization (WHO) (Table 1) struck a compromise between the ideal solutions for these diverse disorders to meet the programmatic goal of a single formulation and packaging for global use in cholera and noncholera diarrheas, in both adults and children. Recently, WHO recommended a new oral solution (Table 1) for all acute diarrheas, including cholera. This new formula would replace the original ORS, which saved millions of lives, with a new formulation containing less sodium and glucose.³ This change was ostensibly to reduce gross stool volume and use of . . . [Full Text of this Article]

Consequence of a Lower-Sodium Solution

Author Affiliations: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn (Dr Hirschhorn); Johns Hopkins School of Medicine, Baltimore, Md (Dr Greenough); University of Arkansas Medical School, Little Rock (Dr Fuchs); and Harvard School of Public Health, Camrbidge, Mass (Dr Cash).

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