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	Since this article does not have an abstract, we have provided the first 126 words of the full text and any section headings.

To the Editor: In their study of prognostic factors for new-onset kidney disease in community-dwelling individuals, Dr Fox and colleagues¹ used the Modification of Diet in Renal Disease (MDRD) Study formula to estimate the glomerular filtration rate (GFR). However, this formula does not appear among the 7 equations for estimation of GFR in a reference that the authors cited.²

Furthermore, we are aware of only a single study that validated the MDRD formula in individuals with normal creatinine serum levels.³ In that study, the accuracy of the MDRD equation was poor, as only 24% of GFR values predicted by the MDRD formula were within the 30% of values as measured by the iohexole technique. Furthermore, the MDRD formula had a large amount of systematic, nonrandom deviation.

Andrea Corsonello, MD
andrea_corsonello@tin.it
Istituto Nazionale di Ricovero e Cura per Anziani (INRCA)
Cosenza, Italy

Claudio Pedone, MD; Raffaele Antonelli Incalzi, MD
Centro di Medicina dell'Invecchiamento

Policlinico A. Gemelli
Università Cattolica del Sacro Cuore
Rome, Italy

1. Fox CS, Martin GL, Leip EP, Culleton B, Wilson PWF, Levy D. Predictors of new-onset kidney disease in a community-based population. JAMA. 2004;291:844-850. FREE FULL TEXT 2. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D, Modification of Diet in Renal Disease Study Group. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med. 1999;130:461-470. FREE FULL TEXT 3. Bostom AG, Kronenberg F, Ritz E. Predictive performance of renal function equations for patients with chronic kidney disease and normal serum creatinine levels. J Am Soc Nephrol. 2002;13:2140-2144. FREE FULL TEXT

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291:2819-2820.

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