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Christopher Newton-Cheh, MD, MPH; Christopher J. O'Donnell, MD, MPH

JAMA. 2004;291:3008-3010.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Myocardial infarction (MI) and related atherosclerotic cardiovascular disease (CVD) are the leading causes of death in men and women.¹ Although much is known regarding risk factors for MI, many questions remain unanswered in the prevention of MI, including what specific genetic variants underlie susceptibility to MI and why there appears to be a protective advantage against MI in women compared with men. The article by Schuit et al² in this issue of JAMA helps address some of these questions but raises others.

Myocardial infarction is a complex trait to which multiple environmental and genetic factors contribute. Risks for MI and other cardiovascular events are substantially increased in adults with a known history of CVD in parents³ or co-twins.⁴ With completion of the human genome sequence, the race has begun among a large and growing number of genetic association studies to test . . . [Full Text of this Article]

Confounding Effects in Case-Cohort Studies.

Author Affiliations: NHLBI Framingham Heart Study, Framingham, Mass; Cardiology Division, Massachusetts General Hospital, Boston; and Broad Institute of Harvard and MIT, Cambridge, Mass.

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