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To the Editor: In their Research Letter, Dr Cooley and colleagues¹ reported that healthy, young, nonobese women with Turner syndrome had more atherogenic lipid profiles than did 46,XX women of the same age and body composition with premature ovarian failure. The authors concluded that the atherogenic lipid profile in Turner syndrome may be caused by haploinsufficiency for a yet-undescribed gene on the X chromosome. Premature ovarian failure, however, is a poorly understood condition with multiple etiologies. In addition to autoimmune or virally mediated ovarian failure, some of the women with premature ovarian failure syndrome were likely to have a mosaic pattern.² Thus, it is unclear that the authors' findings are related to a specific genotype.

My colleagues and I have recently described elevated levels of total and low-density lipoprotein cholesterol in women with normal menstrual cycles and diminished ovarian reserve, as measured by elevated serum levels of cycle day 3 . . . [Full Text of this Article]

Hugh S. Taylor, MD
Department of Obstetrics, Gynecology and Reproductive Sciences
Yale University School of Medicine
New Haven, Conn

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Lipid Profiles in Women With 45,X vs 46,XX Primary Ovarian Failure
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JAMA. 2003;290(16):2127-2128.
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