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In Reply: In the study of Dr Taylor and colleagues,¹ women with regular menstrual cycles and basal FSH levels of 7 mIU/mL or greater had higher cholesterol levels than a similar group with lower FSH levels. Estradiol levels were greater in the group with high FSH levels. Thus, Taylor infers that deficiency for ovarian factor(s) other than estradiol, signaled by elevation of FSH levels, impairs cholesterol metabolism. Although we find this an interesting and novel hypothesis, our results are actually not similar to those of Taylor et al, and do not appear to support this view.

We measured estradiol and FSH levels in our participants at the time of lipid analysis: mean (SD) estradiol levels were similar in the 2 groups (29 [31] pg/mL for premature ovarian failure and 30 [35] pg/mL for Turner syndrome) but FSH levels were higher in women with premature ovarian failure (94 [28] mIU/mL vs . . . [Full Text of this Article]

Carolyn A. Bondy, MD; Vladimir K. Bakalov, MD
National Institute of Child Health and Human Development
National Institutes of Health
Bethesda, Md

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